HIF-1 alpha, also known as hypoxia-inducible factor 1 alpha, is a protein that plays a crucial role in the cellular response to low oxygen levels, or hypoxia. When oxygen levels are low, HIF-1 alpha helps to regulate the expression of genes involved in processes such as angiogenesis (the formation of new blood vessels), glycolysis (the breakdown of glucose for energy), and cell survival. Research in this area focuses on understanding the mechanisms by which HIF-1 alpha is regulated and its role in various physiological and pathological conditions, including cancer, ischemic diseases, and inflammation. Additionally, targeting HIF-1 alpha may have therapeutic potential in these conditions.